2Department of Medical Biochemistry, Erciyes University School of Medicine, Kayseri, Turkey
3Department of Otorhinolaryngology, Patnos State Hospital, Ağrı, Turkey
4Department of Histology and Embryology, Erciyes University School of Medicine, Kayseri, Turkey
5Department of Odiology, Turgut Özal University, Ankara, Turkey
6Department of Otorhinolaryngology, Turgut Özal University School of Medicine, Ankara, Turkey
Abstract
Objective[|]To investigate the changes in otoacoustic emissions (OAEs) for detecting the ototoxicity of cisplatin and to study the possible preventive effect of N-acetylcysteine (NAC) in cisplatin ototoxicity.[¤]Materials and Methods[|]This study was conducted on 21 Wistar albino rats in four groups. Cisplatin, cisplatin plus NAC, NAC alone, and saline were intraperitoneally administered. The rats were anesthetized to study the otoacoustic emissions before and after the experiment.[¤]Results[|]The OAEs were attenuated in the cisplatin group: (−1.31/−4.90), (6.28/4.58), (4.00/0.93), (2.73/−3.74), (2.66/−4.53). The group that received NAC in addition to cisplatin had better OAEs.[¤]Conclusion[|]Cisplatin ototoxicity can be detected by OAE testing in rats, and NAC may reduce the ototoxic effect.[¤]