Pulmonary Sclerosing Hemangioma Exhibiting a High KI-67 Proliferation Index
1Department of Pathology, Faculty of Medicine, Uludağ University, Bursa, Turkey
2Department of Thorasic Surgery, Faculty of Medicine, Uludağ University Bursa, Turkey
J Clin Pract Res 2012; 34(3): 144-147 DOI: 10.5152/etd.2012.28
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Abstract

Pulmonary sclerosing hemangioma (PSH) is a rare pulmonary neoplasm. This tumour was originally thought to be a variant lesion of hemangioma. Today, however, it has been elucidated to be a tumour of epithelial origin derived from the primitive respiratory epithelium. Previous studies have reported a low Ki- 67 proliferation index in cases of pulmonary sclerosing hemangioma (1.4-2.2%). Moreover, the biological nature of this neoplasm,
which rarely tends to metastasise to the lymph nodes, has yet to be thoroughly elucidated. A female patient in whom PSH exhibiting a high Ki-67 proliferation index was detected in the lung during follow-up for lymphoma is reported in the present study. While the Ki 67 proliferation index was 3-4% in some areas, it increased up to 15-20% in other areas. No recurrence or metastases were evident at postoperative follow-up.


Yüksek Kİ-67 Proliferasyon İndeksi Gösteren Pulmoner Sklerozan Hemanjiom
1Department of Pathology, Faculty of Medicine, Uludağ University, Bursa, Turkey
2Department of Thorasic Surgery, Faculty of Medicine, Uludağ University Bursa, Turkey
Journal of Clinical Practice and Research 2012; 3(34): 144-147 DOI: 10.5152/etd.2012.28

Pulmoner sklerozan hemanjiom nadir görülen bir akciğer tümörüdür. Başlangıçda hemanjiomun bir varyantı olduğu düşünülmüştür ancak günümüzde primitif respiratuar epitel hücrelerinden köken aldığı bilinmektedir. Pulmoner sklerozan hemanjiomda Ki-67 proliferasyon indeksinin düşük (%1,4-2,2) olduğu bildirilse de bu tümörün biyolojik davranışı tam olarak bilinmemektedir. Bu yazıda lenfoma tanısı ile takip edilirken
akciğerinde yüksek Ki-67 proliferasyon indeksi gösteren pulmoner sklerozan hemanjiom tespit edilen kadın olgu sunulmuştur. Ki-67 proliferasyon indeksi bazı alanlarda %3-4 iken bazı alanlarda %15-20 olarak tespit edilmiştir. Kontrollerinde rekürrens ya da metastaz izlenmemiştir.