World Health Organization data indicate that as of April 2022, 6.2 million deaths have been reported worldwide due to coronavirus disease 2019 (COVID-19). In Türkiye, official statistics indicate some 15 million cases and a death toll of 98,660. It is important that clinicians consider the possibility of the co-occurrence of other respiratory microorganisms with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the virus that causes COVID-19, when managing treatment, particularly severe COVID-19 patients. The burden and effect of a secondary infection may be significant, especially in patients with chronic disease and advanced age. Proper attention to potential co-infections can prevent COVID-19 progression and the development of complications.