2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
3Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
4Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co
Abstract
Objective[|]This experimental study examines the effect of the antioxidant drug “U-74389G” on rat model, particularly in an ischemia–reperfusion (IR) protocol. The effects of this molecule were biochemically studied using mean creatinine phosphokinase (CPK) levels in blood.[¤]Materials and Methods[|]Forty rats with a mean weight of 231.875 g were used in the study. CPK levels were measured at 60 min (groups A and C) and at 120 min of reperfusion (groups B and D); A and B were groups without U-74389G administration, but C and D were groups with U-74389G administration.[¤]Results[|]U-74389G administration significantly increased CPK levels by 35.34%+17.20% (p=0.0260). Reperfusion time nonsignificantly increased CPK levels by 13.17%+18.05% (p=0.4134). However, U-74389G administration and reperfusion time together non-significantly increased CPK levels by 18.52%+9.44% (p=0.0770).[¤]Conclusion[|]U-74389G administration significantly increased CPK levels for a short term; however, these levels could not be restored, and the restoration capacity increases along with reperfusion time.[¤]