, Slobodan Obradovic 2
, Slobodan Jankovic 5
, Radoslav Romanovic 2
, Nemanja Djenic 2
, Boris Dzudovic 4
, Zoran Jovic 2
, Dragana Malovic 3
, Vesna Subota 4
, Milena Stavric 4
, Farid Ljuca 6
, Zumreta Kusljugic 7
2Clinic for Emergency and Internal Medicine, Military Medical Academy, University of Defence, Belgrade, Serbia; School of Medicine, University of Defence, Belgrade, Serbia
3Clinic for Emergency and Internal Medicine, Military Medical Academy, University of Defence, Belgrade, Serbia
4School of Medicine, University of Defence, Belgrade, Serbia; Institute of Biochemistry, Military Medical Academy, University of Defence, Belgrade, Serbia
5Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
6Department of Physiology, Faculty of Medicine Tuzla, Tuzla, Bosnia and Herzegovina
7Department for Science, Teaching and Clinical Trials, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Abstract
Objective: This study aims to investigate whether the high sensitive C-reactive protein (hsCRP) is associated with an ejection fraction of left ventricle (EFLV) in the early phase of ST-elevation myocardial infarction (STEMI), treated with the primary percutaneous intervention (pPCI), and to establish whether there exists a relationship between its values and the presence of major adverse cardiovascular events (MACE) within six months of pPCI.
Materials and Methods: In this prospective study, 357 patients who were diagnosed with STEMI and who underwent pPCI within 24 hours of pain onset were included. The following were monitored and recorded: 1) hsCRP values, which were measured between 24 and 48 hours of pPCI, 2) EFLV values, which were measured five days after the pPCI, and 3) MACE, which was established within six months of pPCI.
Results: The EFLV values measured five days after the pPCI were significantly lower with increasing hsCRP values (rho=-0.384, p<0.0001). There was a significant difference in hsCRP values between patients who had MACE and those without it (38.35 [98.10] vs. 12.97 [23.80], p=0.0001). In addition, hsCRP values were significantly increased in patients who died during the first six months after the pPCI compared with patients who survived (115.00 [202.80] vs. 15.84 [31.5], p=0.001).
Conclusion: The hsCRP values in patients with STEMI who were treated with the pPCI are related to systolic function in the early phase of STEMI, as well as MACE during the first six months of follow-up.