2Department of Pathology, Cukurova University, Adana, Turkey
Abstract
Purpose: We aimed to evaluate the clinicopathological characteristics and prognostic features of non-Hodgkin lymphoma (NHL) in pediatric patients in Çukurova Region, Turkey.
Materials and Methods: Histopathologically, 24 (63.2%) patients were diagnosed as Burkitt lymphoma, 12 (31.6%) patients were diagnosed as T-cell lymphoblastic lymphoma and 2 (5.2%) patients were diagnosed as diffuse large cell lymphoma. Patients were staged according to Murphy.s classification in children. Treatment protocols of BFM-90 and LSA2L2 were applied to patients.
Results: While mean age of 38 patients with NHL was 75.3±41.5 months, 12 (31.6%) patients were female and 26 (68.4%) patients were male. One (2.6%) patient was evaluated as stage I, 8 (21.1%) patients were as stage II, 18 (47.4%) patients were as stage III and, 11 (28.9 %) patients were as stage IV. Overall survival for 5 years was found as 71%. When overall survival were estimated based on histopathological study, 93%, 56% and %50 were found for T-cell lymphoblastic lymphoma, Burkitt lenfoma and diffuse large cell group, respectively.
Conclusion: The prognosis of NHL cases followed by our clinic varied according to the stage and histopathological type. Although most of our cases were Burkitt or stage III-IV lymphomas, the clinical response to the treatment protocols were similar to the literature.
2Department of Pathology, Cukurova University, Adana, Turkey
Amaç: Bizim amacımız, Çukurova bölgesindeki NHL’lı çocuk hastalarının klinikopatolojik karakteristiklerini ve prognostic bulgularını değerlendirmektir.
Gereç ve Yöntemler: Histopatolojik olarak, 24 hasta Burkitt lenfoma, 12 hasta (%31,6)
Burkitt dışı hasta ve 2 hasta ise büyük hücreli NHL idi. Hastaların evresi Murphy’nin NHL
sınıflanmasına göre yapıldı. Buna göre; bir hasta evre I, 8 hasta evre II, 18 hasta evre III ve
11 hasta ise evre IV idi. Hastalara BFM-90 ve LSA2L2 tedavi protokolü uygulandı.
Bulgular: NHL’lı hastaların ortalama yaşı 75,3±41,5 ay idi. Hastaların 12.si (%31,6) kız hasta
ve 26.sı (%68,4) ise erkek hasta idi. 5 yıllık yaşam olasılığı %71 olarak saptandı. Histopatolojik
tipine göre yaşam olasılığı; T hücreli lenfoblastik lenfomada %93, Burkitt lenfomada %56 ve
Burkitt dışı büyük hücreli lenfomada ise %50 olarak saptandı.
Sonuç: Kliniğimiz tarafından takip edilen NHL’li hastaların prognozu, histopatolojik tip ve
evreye göre değişmekteydi. Bizim olgularımızınn büyük kısmı Burkitt ya da evre III-IV lenfoma
olmasına rağmen, tedavi protokollerine aldığımız cevap literatürle benzerdi.