The mitogen-activated protein kinase (MAPK) signaling pathway is one of the signaling pathways involved in cellular life. Dysregulation of the MAPK signaling pathway is implicated in the emergence of diverse stages of carcinogenesis, including metastasis, angiogenesis, apoptosis, invasion, proliferation and cell differentiation. Therefore, it contributes significantly to the process of carcinogenesis. The mitogen-activated protein kinase signaling pathway presents numerous molecular com-ponents that can be regulated against carcinogenesis. Many studies have shown that polyphenols in various dietary sources have important contributions to the regulation of this pathway. This contribution occurs by inducing cell death, altering immunity, blocking angiogenesis and suppressing cancerous cell growth. Numerous studies have been conducted on this aspect of polyphenolic compounds, with encouraging outcomes. Its clinical efficacy against cancer is also being investigated. This study focuses on the importance of mitogen-activated protein kinase signaling pathway in carcinogenesis by emphasizing the properties of polyphenolic compounds. The study aims to research the clinical effectiveness of polyphenolic compounds in regulating the MAPK signaling pathway against cancer.