Objective: Acne vulgaris (AV) is a common skin disorder. Genotypic variations of antioxidant-related genes may directly influence the function of AV-related genes by mitigating the risk of oxidative stress. This study aimed to investigate the impact of SOD1 +35A/C and GPx-3 +1494A/G gene polymorphisms in patients with AV.
Materials and Methods: The study comprised 81 healthy controls and 81 AV patients. The GPx-3 +1494A/G genotype was evaluated using Allele-Specific Polymerase Chain Reaction (AS-PCR), while the SOD1 +35A/C genotype was analyzed through the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique.
Results: Genotype and allele frequencies of the SOD1 +35A/C gene polymorphism differed significantly between the AV patients and the control group (χ2=13.9, df=2, p=0.001 and χ2=13.1, df=1, p=0.001, respectively). Individuals with the AA genotype, compared to those with the AC genotype, showed an increased incidence of AV (Odds Ratio [OR]=4.81, 95% Confidence Interval [CI]=1.94–11.9, p=0.001). Individuals carrying the A allele were at a higher risk of AV compared to those with the C allele (OR=4.43, 95% CI=1.87–10.4, p=0.001). The AC genotype and C allele were associated with a protective effect in the control group (OR=0.21, 95% CI=0.08–0.52, p=0.001 and OR=0.23, 95% CI=0.10–0.54, p=0.001). However, no significant differences were observed in the GPx-3 +1494A/G genotype and allele frequencies between both groups.
Conclusion: The findings of this study indicate a correlation between the SOD1 +35A/C polymorphism and an increased incidence of AV.