Objective: Mitral valve prolapse (MVP) is a widespread valvulopathy, presents in 2-6% of population and impacts more than 170 million people globally. The objective of this study was to assess p wave dispersion (PWD) in patients with MVP in order to identify the presence of cardiovascular autonomic malfunction, and the probable risk of development of atrial arrhythmias in these patients.
Materials and Methods: The study comprised 40 control people who were in good health (group 1), 41 patients with non-classic MVP (group 2), and 36 patients with classic MVP (group 3). Upon admission, demographic and clinical characteristics were documented. An electrocardiographic assessment was conducted to quantify PWD values for both the patients and the control group.
Results: Minimum p wave duration was lower in classic MVP patients than controls and non-classic MVP patients (63±3,6 vs 70±2,0, p <0,001 ; 63±3,6 vs 63±3,6, p<0,001 respectively). P wave dispersion was higher in classic MVP patients than non-classic MVP patients (47,3±3,2 vs 39,0±2,3, p: 0,001). A noteworthy positive correlation was detected between PWD and Pmax, Pmin, maximal leaflet displacement, maximal leaflet thickness and Lad. (r:0.723, p<0.001; r:-0.771, p<0.001; r:0.557, p<0.001; r:0.770, p<0.001; r:0.517, p<0.001 respectively ) Maximum leaflet thickness, and maximum leaflet displacement were independent predictors of increased PWD in linear regression analysis (β : 1.456 , p<0.001, β : -0.851 , p<0.001).
Conclusion: Patients with classic MVP exhibited prolonged PWD values compared with non-classic MVP patients and normal controls.