Tuberculosis (TB) is an airborne, contagious illness caused by the Mycobacterium tuberculosis, which can affect all tissues and organs, mostly the lungs. TB remains a significant public health problem worldwide. Every year, 10 million people become ill with tuberculosis and 1.5 million people die due to TB. Tuberculosis is the second most common cause of death from communicable diseases globally, following COVID-19. In order to combat tuberculosis globally; The Global Tuberculosis Program is carried out by the WHO (World Health Organization). The WHO began the Directly Observed Treatment Strategy in 1995, the Stop TB Strategy in 2006 and the End TB Strategy in 2015. The End TB Strategy purposes to end the global tuberculosis epidemic by 2035. Due to the COVID-19 pandemic, Global tuberculosis goals were missed or off target. The fight against TB requires continuity. The National Tuberculosis Control Program, which includes the End TB Strategy, continues to be implemented successfully for many years in alignment with global targets in Türkiye. In this article, the changing epidemiology of TB in the world and Türkiye is evaluated and control activities carried out within the scope of combating TB are included.