Sepsis is a global health concern and a medical emergency, defined as the systemic immunological response of the body to an infection, which can lead to severe organ dysfunction and death. This understanding has evolved partly due to advancements in our knowledge of its pathophysiology. The aim of this review is to examine recent advancements in sepsis treatment. Accordingly, the authors reviewed the current literature on sepsis, analyzing advancements in its definitions, treatment guidelines, and management strategies. Sepsis can severely impair immune system functionality, leading to distinct subphenotypes of immunosuppression that increase patients’ susceptibility to infections. These subphenotypes exhibit varying clinical features and responses to treatment, underscoring the necessity of understanding immunosuppression for the advancement of personalized treatment strategies. A transformative shift in sepsis management includes the early recognition of at-risk cases and the prompt, effective use of antibiotics, hemodynamic management, source control, and appropriate supportive care. Although current Surviving Sepsis Campaign guidelines recommend early fluid resuscitation, prompt antibiotic therapy, and monitoring lactate clearance, the authors discuss the objections raised by the Infectious Diseases Society of America regarding these recommendations. In conclusion, initial resuscitation is a critical component of managing sepsis and septic shock, significantly impacting patient outcomes. As our understanding of sepsis continues to evolve, ongoing research and discussions surrounding these guidelines remain essential for improving treatment protocols and enhancing patient care. Given the crucial role of the immune response in sepsis pathophysiology, future research on sepsis management will likely focus on anti-inflammatory mechanisms.