Background: Glioblastoma is the most common malignancy of the central nervous system (CNS). Symptoms vary significantly depending on tumor location and size.
Case Report: A 55-year-old man presented with mild memory deficits, occasional eye twitching, and throat irritation for two months. Magnetic resonance imaging revealed a glioma centered in the piriform cortex, infiltrating the amygdala, hippocampus, bilateral fornices, mammillary bodies, anterior cingulate gyrus, and anterior commissure.
Conclusion: Despite extensive involvement of the limbic system and the Papez circuit, the patient exhibited a remarkable paucity of symptoms and maintained his daily functioning. This discrepancy was elucidated by diffusion tensor imaging tractography, which demonstrated that the tumor primarily displaced, rather than destroyed, the adjacent white matter tracts.