Effect of Omeprazole on Fracture Healing in the Random-Patterned Rat Tibial Fracture Model: An Experimental Study
1Department of Orthopedics and Traumatology, Royal Hospital, Balıkesir, Türkiye
2Department of Orthopedics and Traumatology, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Türkiye
3Department of Orthopedics and Traumatology, Avrupa Hospital, Adana, Türkiye
J Clin Pract Res 2023; 45(5): 447-455 DOI: 10.14744/cpr.2023.09797
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Objective: Fractures represent one of the most common pathologies encountered in ortho-pedic practice. Various factors can impact fracture healing, both negatively and positively. This study aimed to investigate the influence of omeprazole, a proton pump inhibitor pre-scribed to mitigate the side effects of non-steroidal anti-ınflammatory drugs (NSAIDs) used for pain management post-fracture treatment and for deep vein thrombosis (DVT) prophy-laxis, on fracture union through an animal experiment.
Materials and Methods: The study utilized 40 male Wistar-Albino rats obtained from the Experimental Research Laboratory. Employing the simple randomization method, the ani-mals were divided into experimental and control groups, with tibia fractures induced and subsequently fixed intramedullarily. At the conclusion of the sixth week, comprehensive histological, radiological, and biomechanical assessments were conducted to compare frac-ture union and bone biomechanical strength with the control group.
Results: Histological and radiological evaluations were conducted on the tibias of 40 male Wistar-Albino rats. In terms of biomechanical analysis, 14 tibias from the control group and 16 tibias from the study group were examined. Remarkably, the study group exhibited supe-riors union compared to the control group both histologically (p=0.033), radiologically (AP1 view; p=0.040, AP2 view; p=0.036, LAT1 view; p=0.081, LAT2 view; p=0.03), and biomechan-ically (p=0.047), following omeprazole use.
Conclusion: The administration of omeprazole as a proton pump inhibitor following frac-ture treatment contributes positively to the process of fracture healing.