2Department of Anesthesiology, Dokuz Eylül University, İzmir, Turkey
3Department of Anesthesiology, Ankara Numune Education and Research Hospital, Ankara, Turkey
Abstract
Objective[|]This randomized, prospective study was designed to investigate the effect of sevoflurane–nitrous oxide application on the incidence of the hand/arm withdrawal movement caused by rocuronium injection.[¤]Materials and Methods[|]There were 90 individuals undergoing elective surgery included in the study. After preoxygenation, Group T was given intravenous (i.v.) 5 mg/kg thiopental, Group S was given 7% sevoflurane and 40%/60% air/ O2, and Group N was given 7% sevoflurane and 40%/60% N2O/O2 for induction. After the eyelash reflex was lost, 0.6 mg/kg rocuronium was applied intravenously over 5 seconds, and then 2 ml saline was administered. Patients’ response to rocuronium injection was graded by using a 4-point scale (0–3). Hemodynamic data were recorded.[¤]Results[|]After the rocuronium injection, the mean arterial pressure (MAP) and heart rate (HR) values were different between the groups (p<0.05). The incidence of withdrawal movements associated with the injection of rocuronium was observed to be 96.7% in Group T (29/30), 73.3% in Group S (22/30), and 13.3% in Group N (4/30). There were significant differences between the groups (p<0.05). There were differences between Group T and Group S in terms of MAP and 4-point scale, and between Group N and Group S in terms of MAP, HR, and 4-point scale (p<0.05).[¤]Conclusion[|]Adding nitrous oxide to sevoflurane induction in adults reduces the incidence of withdrawal movements associated with rocuronium injection compared to thiopental induction.[¤]