Headache is the most common symptom encountered in clinical practice. Although the causes of primary headaches are common, intracranial space-occupying lesions also cause headaches, albeit more rarely. Rathke cleft cyst (RCC) is a rare, usually asymptomatic cystic lesion of the sellar/suprasellar region. Despite being benign in nature, these should be immediately treated in case they display compressive signs. We report a case of a 36-year-old man with big-sized RCC diagnosed after presenting with a 3-month history of headache in the light of the existing literature.