Objective[|]Cerebrovascular diseases are diseases with a multifactorial etiology, which is affected by genetic and environmental factors, with incidence rates increasing with age around the world. The primary objective of this study was to investigate uric acid and nitric oxide (NO) as risk factors for ischemic stroke patients and to examine the effects of these factors on a patient’s prognosis at an early stage.[¤]Materials and Methods[|]Forty patients who were admitted to the hospital because of ischemic stroke were included in the study.[¤]Results[|]NO levels in the patient group were found to be 34.98 μmol/L, which was significantly higher than that of the control group (p=0.0043); however, uric acid levels in the patient group were found to be 6.54 mg/dl, which was also significantly higher than the control group (p=0.001). In addition, it was shown that the relationship between the NO and uric acid measurements in the patient group was positively and statistically significant (r=0.397, p<0.05).[¤]Conclusion[|]This study indicates that uric acid and NO play a role in the pathogenesis of ischemic stroke; however, they do not contribute to determining the prognosis. It was demonstrated that uric acid is an independent risk factor, when other risk factors are eliminated. When examining the risk factors for ischemic stroke patients, uric acid should be considered and should be among the treatment options.[¤]