E-ISSN 2980-2156
Formerly
Erciyes Medical Journal
Volume : 45 Issue : 6 Year : 2023
To Determine the LDL Phenotype with Lipids, Lipoproteins, and Apoproteins as well as sdLDL by Association Rule Mining [J Clin Pract Res]
J Clin Pract Res. 2023; 45(6): 632-639 | DOI: 10.14744/cpr.2023.09719

To Determine the LDL Phenotype with Lipids, Lipoproteins, and Apoproteins as well as sdLDL by Association Rule Mining

Mehtap Atak1, Mehmet Kıvrak2, Hatice Sevim Nalkıran3, Hüseyin Avni Uydu4, Ömer Şatıroğlu5
1Department of Biochemistry, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Türkiye
2Faculty of Medicine, Biostatistics and Medical Informatics, Recep Tayyip Erdoğan University, Rize, Türkiye
3Faculty of Medicine, Medical Biology, Recep Tayyip Erdoğan University, Rize, Türkiye
4Faculty of Medicine, Medical Biochemistry, Samsun University, Samsun, Türkiye
5Faculty of Medicine, Cardiology, Recep Tayyip Erdoğan University, Rize, Türkiye

BACKGROUND: The atherogenic lipoprotein phenotype is closely related to determining the risk of Coronary Artery Disease (CAD) and monitoring the treatment process. In particular, it is acknowledged that it is critical not only to have high sdLDL but also to have low lbLDL in determining Pattern B.
OBJECTIVES: The aim of this study was to determine the lipid phenotype using Association Rules Mining (ARM) method based on the concentrations of lipids, lipoproteins, and apoproteins as well as sdLDL.
METHODS: The research type was retrospective; the case-control analytical research method was used. Numerical variables were expressed as mean, standard deviation, median, and min-max values. There is a statistically significant difference between the LDL size categories in terms of TG, LDL, HDL, ApoB, ApoE, sdLDL, and lbLDL distributions. ARM was used to detect lipoprotein phenotype.
RESULTS: There is a statistically significant difference between the LDL size categories in TG, LDL, HDL, ApoB, ApoE, sdLDL, and lbLDL distributions (p_TG<0.001, p_LDL=0.03, p_HDL<0.001, p_ApoB=0.016, p_ApoE=0.004, p_sdLDL< 0.001, and p_lbLDL<0.001). ARM method revealed that the probability of phenotype B was found to be 100% for values in the range of 15.5-109 and 0-31.5 for sdLDL and lbLDL, respectively.
CONCLUSIONS: This study presents a current approach to the detection of lipoprotein phenotypes using ARM, and further supports the close relationship between atherogenic phenotype and sdLDL.

Keywords: Lipoproteins, LDL Phenotype, Coronary Artery Disease, Association Rules Mining.

Mehtap Atak, Mehmet Kıvrak, Hatice Sevim Nalkıran, Hüseyin Avni Uydu, Ömer Şatıroğlu. To Determine the LDL Phenotype with Lipids, Lipoproteins, and Apoproteins as well as sdLDL by Association Rule Mining. J Clin Pract Res. 2023; 45(6): 632-639

Corresponding Author: Mehtap Atak, Türkiye
Manuscript Language: English
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