Tick-borne encephalitis (TBE) exists over a wide geographical area worldwide. In here, a clinical case with TBE was presented. A 34 years old man complained of weakness, high fever with chills, body aches, headache, malaise. He was hospitalized in the Infectious Diseases clinic. He gave a history of the visit to an endemic area of TBE. Laboratory examination showed leukocytosis, neutrophilosis and ESR acceleration. Upon the clinical diagnosis of “Fever of unknown origin” levofloxacin and metronidazole, ceftazidime were started. On the third day of treatment, neurological symptoms of encephalitis developed. The patient was transferred to the intensive care unit. ELISA test for TBE virus IgM was positive. Cerebrospinal fluid (CSF) revealed serous meningitis. TBE was diagnosed. Treatment with human immunoglobulin TBE, glucocorticoid, and diuretics were administered. The outcome of the disease was favorable. The physicians should be aware about the clinical presentations of TBE in endemic areas.